Active: Ann Rheum Dis Clear all

GWAS 2023-11-02

Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study.

Luo Y, Ferrada MA et al.

Ann Rheum Dis

Objective: Relapsing polychondritis (RP) is a systemic inflammatory disease of unknown aetiology. Th...

Relapsing polychondritis

2989

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-20

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy.

Alonso N, Albagha OME et al.

Ann Rheum Dis

Objectives: Teriparatide (TPTD) is an effective treatment for osteoporosis but the individual respon...

Response of lumbar spine BMD to teriparatide in osteoporosis

437

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-17

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Styrkarsdottir U, Stefansdottir L et al.

Ann Rheum Dis

Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is...

Erosive hand osteoarthritis

552164

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-16

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Ortiz-Fernández L, Carmona EG et al.

Ann Rheum Dis

Objectives: The number of susceptibility loci currently associated with vasculitis is lower than in ...

Vasculitis (pleiotropy)

38262

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-14

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.

Henkel C, Styrkársdóttir U et al.

Ann Rheum Dis

Objectives: Osteoarthritis is a common and severe, multifactorial disease with a well-established ge...

Surgical knee osteoarthritis

661143

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-25

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

Saevarsdottir S, Stefansdottir L et al.

Ann Rheum Dis

Objectives: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA ...

Rheumatoid arthritis

1026690

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-29

Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.

Rahman MS, Winsvold BS et al.

Ann Rheum Dis

Background and objectives: Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgi...

Chronic widespread musculoskeletal pain

Replicated

292923

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-08

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Sandoval-Plata G, Morgan K et al.

Ann Rheum Dis

Objectives: To perform a genome-wide association study (GWAS) of gout cases versus asymptomatic hype...

Gout

Replicated

71473

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-11

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.

Ha E, Bae SC et al.

Ann Rheum Dis

Objectives: Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes ha...

Rheumatoid arthritis

311292

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-03

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

Yin X, Kim K et al.

Ann Rheum Dis

Objective: Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with near...

Systemic lupus erythematosus

208370

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-26

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.

López-Isac E, Smith SL et al.

Ann Rheum Dis

Objectives: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic dis...

Arthritis (juvenile idiopathic)

Replicated

31138

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-14

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.

Boer CG, Yau MS et al.

Ann Rheum Dis

Despite recent advances in the understanding of the genetic architecture of osteoarthritis (OA), onl...

Hand osteoarthritis severity (hand Klsum)

Replicated

6032

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study.

Luo Y, Ferrada MA et al.

Ann Rheum Dis

Relapsing polychondritis

2023-11-02

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy.

Alonso N, Albagha OME et al.

Ann Rheum Dis

Response of lumbar spine BMD to teriparatide in osteoporosis

2023-03-20

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Styrkarsdottir U, Stefansdottir L et al.

Ann Rheum Dis

Erosive hand osteoarthritis

2023-03-17

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Ortiz-Fernández L, Carmona EG et al.

Ann Rheum Dis

Vasculitis (pleiotropy)

2023-02-16

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.

Henkel C, Styrkársdóttir U et al.

Ann Rheum Dis

Surgical knee osteoarthritis

2022-11-14

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

Saevarsdottir S, Stefansdottir L et al.

Ann Rheum Dis

Rheumatoid arthritis

2022-04-25

Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.

Rahman MS, Winsvold BS et al.

Ann Rheum Dis

Chronic widespread musculoskeletal pain

2021-04-29

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Sandoval-Plata G, Morgan K et al.

Ann Rheum Dis

Gout

2021-04-08

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.

Ha E, Bae SC et al.

Ann Rheum Dis

Rheumatoid arthritis

2020-12-11

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

Yin X, Kim K et al.

Ann Rheum Dis

Systemic lupus erythematosus

2020-12-03

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.

López-Isac E, Smith SL et al.

Ann Rheum Dis

Arthritis (juvenile idiopathic)

2020-10-26

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.

Boer CG, Yau MS et al.

Ann Rheum Dis

Hand osteoarthritis severity (hand Klsum)

2020-10-14

Health & Traits Publications

Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study.

Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy.

Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

Genome-wide association study identifies <i>RNF123</i> locus as associated with chronic widespread musculoskeletal pain.

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify <i>WNT9A</i> as novel osteoarthritis gene.