Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.
Ortiz-Fernández L, Carmona EG, Kerick M et al.
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Abstract
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Objectives: The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap.
8,467 European, Turkish, Asian or Middle Eastern ancestry cases, 29,795 European, Turkish, Asian or Middle Eastern ancestry controls
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