Active: Genome Med Clear all

GWAS 2025-10-09

Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram.

Sieliwonczyk E, Sau A et al.

Genome Med

Electrocardiograms (ECGs) are widely used to assess cardiac health, but traditional clinical interpr...

Machine learning derived ECG trait 2

Replicated

50105

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-08

Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.

Chen L, Tan KM et al.

Genome Med

Phenotypic age (PhenoAge), a widely used marker of biological aging, has been shown to be a robust p...

Phenotypic age acceleration

882

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-13

Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.

Tian J, Zhang M et al.

Genome Med

Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely inte...

Colorectal cancer

839703

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-05

Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.

Akinyemi RO, Tiwari HK et al.

Genome Med

African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of s...

Ischemic stroke

3421

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-08

Rare copy-number variants as modulators of common disease susceptibility.

Auwerx C, Jõeloo M et al.

Genome Med

Copy-number variations (CNVs) have been associated with rare and debilitating genomic disorders (GDs...

ICD10 M32: systemic lupus erythematosus (CNV U-shape model)

Replicated

332327

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-21

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Khan Z, Jung M et al.

Genome Med

Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome s...

Chemotherapy induced time to first peripheral neuropathy in cancer

4900

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-11

Sex differences in the polygenic architecture of hearing problems in adults.

De Angelis F, Zeleznik OA et al.

Genome Med

Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its ...

Hearing problems

Replicated

748668

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-03

Identification of specific susceptibility loci for the early-onset colorectal cancer.

Wang H, Cai Y et al.

Genome Med

The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising r...

Early onset colorectal cancer

21441

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-14

Ultra-low-coverage genome-wide association study-insights into gestational age using 17,844 embryo samples with preimplantation genetic testing.

Li S, Yan B et al.

Genome Med

Very low-coverage (0.1 to 1×) whole genome sequencing (WGS) has become a promising and affordable ap...

Gestational age (fetal effect)

1744

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-09

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative.

Johnson R, Ding Y et al.

Genome Med

Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and of...

Chronic kidney disease

22184

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-22

Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer.

Dong Q, Song N et al.

Genome Med

Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with spec...

Epigenetic age acceleration (Hannum) in childhood cancer survivors

2640

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-09

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

Caron B, Patin E et al.

Genome Med

Blood plasma proteins play an important role in immune defense against pathogens, including cytokine...

ACE plasma levels

400

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram.

Sieliwonczyk E, Sau A et al.

Genome Med

Machine learning derived ECG trait 2

2025-10-09

Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.

Chen L, Tan KM et al.

Genome Med

Phenotypic age acceleration

2024-11-08

Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.

Tian J, Zhang M et al.

Genome Med

Colorectal cancer

2024-06-13

Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.

Akinyemi RO, Tiwari HK et al.

Genome Med

Ischemic stroke

2024-02-05

Rare copy-number variants as modulators of common disease susceptibility.

Auwerx C, Jõeloo M et al.

Genome Med

ICD10 M32: systemic lupus erythematosus (CNV U-shape model)

2024-01-08

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Khan Z, Jung M et al.

Genome Med

Chemotherapy induced time to first peripheral neuropathy in cancer

2023-06-21

Sex differences in the polygenic architecture of hearing problems in adults.

De Angelis F, Zeleznik OA et al.

Genome Med

Hearing problems

2023-05-11

Identification of specific susceptibility loci for the early-onset colorectal cancer.

Wang H, Cai Y et al.

Genome Med

Early onset colorectal cancer

2023-03-03

Ultra-low-coverage genome-wide association study-insights into gestational age using 17,844 embryo samples with preimplantation genetic testing.

Li S, Yan B et al.

Genome Med

Gestational age (fetal effect)

2023-02-14

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative.

Johnson R, Ding Y et al.

Genome Med

Chronic kidney disease

2022-09-09

Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer.

Dong Q, Song N et al.

Genome Med

Epigenetic age acceleration (Hannum) in childhood cancer survivors

2022-03-22

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

Caron B, Patin E et al.

Genome Med

ACE plasma levels

2022-03-09