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GWAS Study

Sex differences in the polygenic architecture of hearing problems in adults.

De Angelis F, Zeleznik OA, Wendt FR et al.

37165447 PubMed ID
GWAS Study Type
748668 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DA
De Angelis F
ZO
Zeleznik OA
WF
Wendt FR
PG
Pathak GA
TD
Tylee DS
DL
De Lillo A
KD
Koller D
CB
Cabrera-Mendoza B
CR
Clifford RE
MA
Maihofer AX
NC
Nievergelt CM
CG
Curhan GC
CS
Curhan SG
PR
Polimanti R
Chapter II

Abstract

Summary of the research findings

Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP biology and epidemiology are still insufficiently investigated by large-scale genetic studies.

501,825 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

748668
Total Participants
GWAS
Study Type
Yes
Replicated
226,043 European ancestry individuals, 6,636 African ancestry individuals, 980 admixed American ancestry individuals, 8,876 Central Asian ancestry, South Asian ancestry individuals, 2,709 East Asian ancestry individuals, 1,599 Middle Eastern ancestry individuals
Replication Participants
European, African unspecified, Hispanic or Latin American, Central Asian, South Asian, East Asian, Greater Middle Eastern (Middle Eastern, North African or Persian)
Ancestry
U.K., U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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