Genetic liability to psoriasis predicts severe disease outcomes.
Saklatvala JR, Lessard S, Teder-Laving M et al.
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Abstract
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Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve allocation of clinical resources and enable earlier intervention to prevent disease progression, and a genetic biomarker would be cost-effective, stable over time, and unaffected by treatment or comorbidity.
9,738 European ancestry individuals with severe psoriasis, 35,166 European ancestry individuals with psoriasis but no evidence for severe disease
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