Active: J Hepatol Clear all

GWAS 2024-11-13

Genetic study of intrahepatic cholestasis of pregnancy in Chinese women unveils East Asian etiology linked to historic HBV epidemic.

Liu Y, Wei Y et al.

J Hepatol

Background & aims: Intrahepatic cholestasis of pregnancy (ICP) is the most common and high-risk ...

Total bile acid levels in pregnancy

Replicated

114631

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-10

Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.

Glessner JT, Ningappa MB et al.

J Hepatol

Background & aims: Biliary atresia (BA) is poorly understood and leads to liver transplantation ...

Biliary atresia

5465

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-22

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Backgrounds & aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoim...

Primary biliary cholangitis

24510

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-13

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort.

Anstee QM, Darlay R et al.

J Hepatol

Background & aims: Genetic factors associated with non-alcoholic fatty liver disease (NAFLD) rem...

Hepatic steatosis in non-alcoholic fatty liver disease

Replicated

1973

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-02

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Parisinos CA, Wilman HR et al.

J Hepatol

Background & aims: MRI-based corrected T1 (cT1) is a non-invasive method to grade the severity o...

Liver fat content (MRI proton density fat fraction measure)

14440

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-18

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.

Wilman HR, Parisinos CA et al.

J Hepatol

Background & aims: Excess liver iron content is common and is linked to the risk of hepatic and ...

Liver iron content

Replicated

9802

Participants

N/A

Studies

Details PubMed

GWAS 2014-10-18

Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis.

de Tayrac M, Roth MP et al.

J Hepatol

Background & aims: Hereditary hemochromatosis (HH) is the most common form of genetic iron loadi...

Hereditary hemochromatosis-related traits (HFE mutation homozygotes)

Replicated

1220

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-12

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

Urabe Y, Ochi H et al.

J Hepatol

Background & aims: We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV...

Hepatitis C induced liver cirrhosis

Replicated

6472

Participants

N/A

Studies

Details PubMed

GWAS 2011-05-20

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

Thompson AJ, Clark PJ et al.

J Hepatol

Background & aims: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting....

IFN-related cytopenia

1284

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic study of intrahepatic cholestasis of pregnancy in Chinese women unveils East Asian etiology linked to historic HBV epidemic.

Liu Y, Wei Y et al.

J Hepatol

Total bile acid levels in pregnancy

2024-11-13

Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.

Glessner JT, Ningappa MB et al.

J Hepatol

Biliary atresia

2023-08-10

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Primary biliary cholangitis

2021-05-22

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort.

Anstee QM, Darlay R et al.

J Hepatol

Hepatic steatosis in non-alcoholic fatty liver disease

2020-04-13

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Parisinos CA, Wilman HR et al.

J Hepatol

Liver fat content (MRI proton density fat fraction measure)

2020-04-02

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.

Wilman HR, Parisinos CA et al.

J Hepatol

Liver iron content

2019-06-18

Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis.

de Tayrac M, Roth MP et al.

J Hepatol

Hereditary hemochromatosis-related traits (HFE mutation homozygotes)

2014-10-18

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

Urabe Y, Ochi H et al.

J Hepatol

Hepatitis C induced liver cirrhosis

2013-01-12

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

Thompson AJ, Clark PJ et al.

J Hepatol

IFN-related cytopenia

2011-05-20