Active: Circ Genom Precis Med Clear all

GWAS 2025-10-07

New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.

Lu C, McGurk KA et al.

Circ Genom Precis Med

Cardiac remodeling occurs in the mature heart and is a cascade of adaptations in response to stress,...

Average circumferential strain on AHA 5

33156

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-05

Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy.

Yu M, Harper AR et al.

Circ Genom Precis Med

A large proportion of genetic risk remains unexplained for structural heart disease involving the in...

Interventricular septum cross-sectional area

306

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-12

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.

Saad M, El-Menyar A et al.

Circ Genom Precis Med

Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about...

Coronary heart disease

Replicated

1431297

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-11

Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial.

Murphy WA, Lin N et al.

Circ Genom Precis Med

Statin-associated muscle symptoms (SAMS) are the most frequently reported adverse events for statin ...

Statin intolerance or statin-associated muscle symptoms

10617

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-04

Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Yang Y, Bartz TM et al.

Circ Genom Precis Med

Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular disea...

High-sensitivity cardiac troponin T levels

24616

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-28

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Blacks.

Olson NC, Raffield LM et al.

Circ Genom Precis Med

suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an important biomarker of co...

Soluble urokinase plasminogen activator receptor levels

3492

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-04

Genome-Wide Association Study of Peripheral Artery Disease.

van Zuydam NR, Stiby A et al.

Circ Genom Precis Med

Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high...

Peripheral artery disease

Replicated

727992

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-31

Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.

Yu M, Kyryachenko S et al.

Circ Genom Precis Med

Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects 1 in 40 in the general ...

Mitral valve prolapse

8778

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-28

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.

Choi SH, Jurgens SJ et al.

Circ Genom Precis Med

Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden...

RR interval

Replicated

27967

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-09

Multiethnic Genome-wide Association Study of Subclinical Atherosclerosis in Individuals with Type 2 Diabetes.

Lu Y, Dimitrov L et al.

Circ Genom Precis Med

Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of...

Carotid artery intima-media thickness in type 2 diabetes

838

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-22

Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Young WJ, Warren HR et al.

Circ Genom Precis Med

ECG markers of ventricular depolarization and repolarization are associated with an increased risk o...

Calcium levels

305349

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-09

Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT.

Dubé MP, Legault MA et al.

Circ Genom Precis Med

The randomized, placebo-controlled COLCOT (Colchicine Cardiovascular Outcomes Trial) has shown the b...

Cardiovascular event in colchicine-treated recent myocardial infarction (time to event)

702

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.

Lu C, McGurk KA et al.

Circ Genom Precis Med

Average circumferential strain on AHA 5

2025-10-07

Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy.

Yu M, Harper AR et al.

Circ Genom Precis Med

Interventricular septum cross-sectional area

2023-04-05

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.

Saad M, El-Menyar A et al.

Circ Genom Precis Med

Coronary heart disease

2022-10-12

Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial.

Murphy WA, Lin N et al.

Circ Genom Precis Med

Statin intolerance or statin-associated muscle symptoms

2022-05-11

Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Yang Y, Bartz TM et al.

Circ Genom Precis Med

High-sensitivity cardiac troponin T levels

2021-11-04

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Blacks.

Olson NC, Raffield LM et al.

Circ Genom Precis Med

Soluble urokinase plasminogen activator receptor levels

2021-10-28

Genome-Wide Association Study of Peripheral Artery Disease.

van Zuydam NR, Stiby A et al.

Circ Genom Precis Med

Peripheral artery disease

2021-10-04

Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.

Yu M, Kyryachenko S et al.

Circ Genom Precis Med

Mitral valve prolapse

2021-08-31

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.

Choi SH, Jurgens SJ et al.

Circ Genom Precis Med

RR interval

2021-07-28

Multiethnic Genome-wide Association Study of Subclinical Atherosclerosis in Individuals with Type 2 Diabetes.

Lu Y, Dimitrov L et al.

Circ Genom Precis Med

Carotid artery intima-media thickness in type 2 diabetes

2021-07-09

Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Young WJ, Warren HR et al.

Circ Genom Precis Med

Calcium levels

2021-04-22

Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT.

Dubé MP, Legault MA et al.

Circ Genom Precis Med

Cardiovascular event in colchicine-treated recent myocardial infarction (time to event)

2021-02-09