Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial.
Murphy WA, Lin N, Damask A et al.
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Abstract
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Statin-associated muscle symptoms (SAMS) are the most frequently reported adverse events for statin therapies. Previous studies have reported an association between the p.Val174Ala missense variant in SLCO1B1 and SAMS in simvastatin-treated subjects; however, evidence for genetic predictors of SAMS in atorvastatin- or rosuvastatin-treated subjects is currently lacking.
819 European ancestry cases, 8,365 European ancestry controls, 49 Asian ancestry cases, 546 Asian ancestry controls, 14 Black cases, 282 Black controls, 12 cases, 530 controls
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