Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT.
Dubé MP, Legault MA, Lemaçon A et al.
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Abstract
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The randomized, placebo-controlled COLCOT (Colchicine Cardiovascular Outcomes Trial) has shown the benefits of colchicine 0.5 mg daily to lower the rate of ischemic cardiovascular events in patients with a recent myocardial infarction. Here, we conducted a post hoc pharmacogenomic study of COLCOT with the aim to identify genetic predictors of the efficacy and safety of treatment with colchicine.
39 European ancestry cases, 663 European ancestry controls
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