Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.
Choi SH, Jurgens SJ, Haggerty CM et al.
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Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden cardiac death (SCD) risk. While the genetics of arrhythmia syndromes have been studied, relations between electrocardiographic intervals and rare genetic variation at a population level are poorly understood.
5,034 African American individuals, 615 admixed American individuals, 17,777 European ancestry individuals, 727 East Asian ancestry individuals, 56 South Asian ancestry individuals, 3,758 individuals
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