Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.
Saad M, El-Menyar A, Kunji K et al.
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Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry cohorts.
1,014 Greater Middle Eastern (Middle Eastern, North African or Persian) cases, 6,009 Greater Middle Eastern (Middle Eastern, North African or Persian) controls
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