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GWAS 2022-07-26

GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.

Schröder J, Chegwidden L et al.

Gut

Objective: Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal ...

Barrett's esophagus or Esophageal adenocarcinoma

49266

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-04

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis ...

Hepatocellular carcinoma in alcohol related cirrhosis

Replicated

3080

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-29

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Ong JS, An J et al.

Gut

Objective: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributab...

Gastroesophageal reflux disease

Replicated

2192831

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-22

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

Zheng T, Ellinghaus D et al.

Gut

Objective: Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the popula...

Haemorrhoidal disease

944133

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-25

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Huyghe JR, Harrison TA et al.

Gut

Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical fo...

Distal/Left-sided colorectal cancer

94747

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-05

Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.

Yan C, Zhu M et al.

Gut

Objective: Although a subset of genetic loci have been associated with gastric cancer (GC) risk, the...

Gastric cancer

Replicated

24555

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-19

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.

Schafmayer C, Harrison JW et al.

Gut

Objective: Diverticular disease is a common complex disorder characterised by mucosal outpouchings o...

Diverticular disease

Replicated

487188

Participants

N/A

Studies

Details PubMed

GWAS 2017-08-04

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Alberts R, de Vries EMG et al.

Gut

Objective: Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct dis...

Autoimmune hepatitis in primary sclerosing cholangitis

3266

Participants

N/A

Studies

Details PubMed

GWAS 2017-07-28

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Rosendahl J, Kirsten H et al.

Gut

Objective: Alcohol-related pancreatitis is associated with a disproportionately large number of hosp...

Alcoholic chronic pancreatitis

7999

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-27

Genome-wide association study identiﬁes HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failure.

Tan W, Xia J et al.

Gut

Objective: Acute-on-chronic liver failure (ACLF) is an extreme condition after severe acute exacerba...

Acute-on-chronic liver failure in hepatitis B

Replicated

3367

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-24

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Kim HS, Cheon JH et al.

Gut

Objective: Myelosuppression is a life-threatening complication of thiopurine therapy, and the incide...

Thiopurine-induced leukopenia in inflammatory bowel disease

Replicated

1034

Participants

N/A

Studies

Details PubMed

GWAS 2015-12-23

Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.

Wang Z, Dai J et al.

Gut

Objective: Although several genome-wide association studies (GWAS) of non-cardia gastric cancer have...

Non-cardia gastric cancer

Replicated

15202

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.

Schröder J, Chegwidden L et al.

Gut

Barrett's esophagus or Esophageal adenocarcinoma

2022-07-26

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Hepatocellular carcinoma in alcohol related cirrhosis

2022-07-04

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Ong JS, An J et al.

Gut

Gastroesophageal reflux disease

2021-06-29

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

Zheng T, Ellinghaus D et al.

Gut

Haemorrhoidal disease

2021-04-22

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Huyghe JR, Harrison TA et al.

Gut

Distal/Left-sided colorectal cancer

2021-02-25

Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.

Yan C, Zhu M et al.

Gut

Gastric cancer

2019-08-05

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.

Schafmayer C, Harrison JW et al.

Gut

Diverticular disease

2019-01-19

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Alberts R, de Vries EMG et al.

Gut

Autoimmune hepatitis in primary sclerosing cholangitis

2017-08-04

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Rosendahl J, Kirsten H et al.

Gut

Alcoholic chronic pancreatitis

2017-07-28

Genome-wide association study identiﬁes HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failure.

Tan W, Xia J et al.

Gut

Acute-on-chronic liver failure in hepatitis B

2017-01-27

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Kim HS, Cheon JH et al.

Gut

Thiopurine-induced leukopenia in inflammatory bowel disease

2016-08-24

Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.

Wang Z, Dai J et al.

Gut

Non-cardia gastric cancer

2015-12-23