A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.
Kim HS, Cheon JH, Jung ES et al.
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Abstract
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Objective: Myelosuppression is a life-threatening complication of thiopurine therapy, and the incidence of thiopurine-induced myelosuppression is higher in East Asians than in Europeans. We investigated genetic factors associated with thiopurine-induced leukopenia in patients with IBD.
113 Korean ancestry cases, 154 Korean ancestry controls
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