Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.
Zheng T, Ellinghaus D, Juzenas S et al.
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Objective: Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date.
218,920 European ancestry cases, 725,213 European ancestry controls
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