First genome-wide association study for lymphatic filariasis in a West African population points to an HLA-mediated disease pathophysiology.
Grover S, Opoku VS, Debrah LB et al.
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Objectives: Lymphatic filariasis (LF) represents a parasitic disease caused by filarial nematodes. Although some infected individuals present an asymptomatic course, others suffer severe chronic lymphatic pathology, including lymphedema, hydrocele, and elephantiasis. Several studies have shown that host genetic factors influence LF susceptibility and chronic pathology. The current study aimed to conduct the first genome-wide association study to systematically determine LF susceptibility.
1,459 Ghanaian ancestry cases, 1,492 Ghanaian ancestry controls
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