Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
Wineinger NE, Patki A, Meyers KJ et al.
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Abstract
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Aortic root diameter is a clinically relevant trait due to its known relationship with the pathogenesis of aortic regurgitation and risk for aortic dissection. African Americans are an understudied population despite a particularly high burden of cardiovascular diseases. We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects.
1,086 African American individuals
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