A genome-wide association study of amygdala activation in youths with and without bipolar disorder.
Liu X, Akula N, Skup M et al.
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Abstract
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Objective: Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype.
36 European ancestry BD cases, 21 European ancestry controls, 1 African American BD case, 5 African American controls, 2 BD cases, 3 controls
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