Genome-wide analysis of hepatic lipid content in extreme obesity.
DiStefano JK, Kingsley C, Craig Wood G et al.
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Abstract
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Aims: Individuals with type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease (NAFLD), and NAFLD patients are also at greater risk for developing type 2 diabetes. Although the relationship between type 2 diabetes and NAFLD is highly interconnected, the pathogenic mechanisms linking the two diseases are poorly understood. The goal of this study was to identify genetic determinants of hepatic lipid accumulation through association analysis using histological phenotypes in obese individuals.
1,868 European ancestry cases
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