Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study.
Patel B, Kleeman SO, Neavin D et al.
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Abstract
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Trigger finger and carpal tunnel syndrome are the two most common non-traumatic connective tissue disorders of the hand. Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. However, this phenotypic association is poorly understood. Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases.
2,908 European ancestry cases, 436,579 European ancestry controls
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