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GWAS Study

Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response.

Esposito M, Minnai F, Copetti M et al.

38575714 PubMed ID
GWAS Study Type
1351 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

EM
Esposito M
MF
Minnai F
CM
Copetti M
MG
Miscio G
PR
Perna R
PA
Piepoli A
DV
De Vincentis G
BM
Benvenuto M
DP
D'Addetta P
CS
Croci S
BM
Baldassarri M
BM
Bruttini M
FC
Fallerini C
BR
Brugnoni R
CP
Cavalcante P
BF
Baggi F
CE
Corsini EMG
CE
Ciusani E
AF
Andreetta F
DT
Dragani TA
FM
Fratelli M
CM
Carella M
MR
Mantegazza RE
RA
Renieri A
CF
Colombo F
Chapter II

Abstract

Summary of the research findings

Since the beginning of the anti-COVID-19 vaccination campaign, it has become evident that vaccinated subjects exhibit considerable inter-individual variability in the response to the vaccine that could be partly explained by host genetic factors. A recent study reported that the immune response elicited by the Oxford-AstraZeneca vaccine in individuals from the United Kingdom was influenced by a specific allele of the human leukocyte antigen gene HLA-DQB1.

1,351 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

1351
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Italy
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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