A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.
Schwantes-An TH, Whitfield JB, Aithal GP et al.
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Abstract
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Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with alcohol-associated cirrhosis (ALC) versus drinkers who did not have evidence of liver fibrosis/cirrhosis.
1,840 European ancestry cases, 2,465 European ancestry controls
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