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GWAS Study

Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.

Schymick JC, Scholz SW, Fung HC et al.

17362836 PubMed ID
GWAS Study Type
547 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SJ
Schymick JC
SS
Scholz SW
FH
Fung HC
BA
Britton A
AS
Arepalli S
GJ
Gibbs JR
LF
Lombardo F
MM
Matarin M
KD
Kasperaviciute D
HD
Hernandez DG
CC
Crews C
BL
Bruijn L
RJ
Rothstein J
MG
Mora G
RG
Restagno G
CA
Chiò A
SA
Singleton A
HJ
Hardy J
TB
Traynor BJ
Chapter II

Abstract

Summary of the research findings

The cause of sporadic ALS is currently unknown. Despite evidence for a role for genetics, no common genetic variants have been unequivocally linked to sporadic ALS. We sought to identify genetic variants associated with an increased or decreased risk for developing ALS in a cohort of American sporadic cases.

276 European ancestry cases, 271 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

547
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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