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GWAS Study

Whole-genome analysis of sporadic amyotrophic lateral sclerosis.

Dunckley T, Huentelman MJ, Craig DW et al.

17671248 PubMed ID
GWAS Study Type
1694 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DT
Dunckley T
HM
Huentelman MJ
CD
Craig DW
PJ
Pearson JV
SS
Szelinger S
JK
Joshipura K
HR
Halperin RF
SC
Stamper C
JK
Jensen KR
LD
Letizia D
HS
Hesterlee SE
PA
Pestronk A
LT
Levine T
BT
Bertorini T
GM
Graves MC
MT
Mozaffar T
JC
Jackson CE
BP
Bosch P
MA
McVey A
DA
Dick A
BR
Barohn R
LC
Lomen-Hoerth C
RJ
Rosenfeld J
OD
O'connor DT
ZK
Zhang K
CR
Crook R
RH
Ryberg H
HM
Hutton M
KJ
Katz J
SE
Simpson EP
MH
Mitsumoto H
BR
Bowser R
MR
Miller RG
AS
Appel SH
SD
Stephan DA
Chapter II

Abstract

Summary of the research findings

Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes.

386 European ancestry cases, 542 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

1694
Total Participants
GWAS
Study Type
Yes
Replicated
901 cases and 1,025 controls of European, Hispanic, Asian, American Indian, Pacific Islander, and other ancestries
Replication Participants
European, Native American, Other, Oceanian, African unspecified, Asian unspecified, Hispanic or Latin American
Ancestry
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.