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GWAS Study

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.

Smith NL, Chen MH, Dehghan A et al.

20231535 PubMed ID
GWAS Study Type
22883 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SN
Smith NL
CM
Chen MH
DA
Dehghan A
SD
Strachan DP
BS
Basu S
SN
Soranzo N
HC
Hayward C
RI
Rudan I
SM
Sabater-Lleal M
BJ
Bis JC
DM
de Maat MP
RA
Rumley A
KX
Kong X
YQ
Yang Q
WF
Williams FM
VV
Vitart V
CH
Campbell H
MA
Mälarstig A
WK
Wiggins KL
VD
Van Duijn CM
MW
McArdle WL
PJ
Pankow JS
JA
Johnson AD
SA
Silveira A
MB
McKnight B
UA
Uitterlinden AG
AN
Aleksic N
MJ
Meigs JB
PA
Peters A
KW
Koenig W
CM
Cushman M
KS
Kathiresan S
RJ
Rotter JI
BE
Bovill EG
HA
Hofman A
BE
Boerwinkle E
TG
Tofler GH
PJ
Peden JF
PB
Psaty BM
LF
Leebeek F
FA
Folsom AR
LM
Larson MG
ST
Spector TD
WA
Wright AF
WJ
Wilson JF
HA
Hamsten A
LT
Lumley T
WJ
Witteman JC
TW
Tang W
OC
O'Donnell CJ
Chapter II

Abstract

Summary of the research findings

Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.

15,279 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

22883
Total Participants
GWAS
Study Type
Yes
Replicated
up to 7,604 European ancestry individuals
Replication Participants
European
Ancestry
U.S., Sweden
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.