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GWAS Study

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.

Villard E, Perret C, Gary F et al.

21459883 PubMed ID
GWAS Study Type
4754 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

VE
Villard E
PC
Perret C
GF
Gary F
PC
Proust C
DG
Dilanian G
HC
Hengstenberg C
RV
Ruppert V
AE
Arbustini E
WT
Wichter T
GM
Germain M
DO
Dubourg O
TL
Tavazzi L
AM
Aumont MC
DP
DeGroote P
FL
Fauchier L
TJ
Trochu JN
GP
Gibelin P
AJ
Aupetit JF
SK
Stark K
EJ
Erdmann J
HR
Hetzer R
RA
Roberts AM
BP
Barton PJ
RV
Regitz-Zagrosek V
AU
Aslam U
DL
Duboscq-Bidot L
MM
Meyborg M
MB
Maisch B
MH
Madeira H
WA
Waldenström A
GE
Galve E
CJ
Cleland JG
DR
Dorent R
RG
Roizes G
ZT
Zeller T
BS
Blankenberg S
GA
Goodall AH
CS
Cook S
TD
Tregouet DA
TL
Tiret L
IR
Isnard R
KM
Komajda M
CP
Charron P
CF
Cambien F
Chapter II

Abstract

Summary of the research findings

Aims: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM.

1,179 European ancestry cases, 1,108 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

4754
Total Participants
GWAS
Study Type
Yes
Replicated
1,165 European ancestry cases, 1,302 European ancestry controls
Replication Participants
European
Ancestry
Germany, U.K., Italy, France
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.