Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.
Roselli C, Yu M, Nauffal V et al.
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Aims: Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical therapy is available for this disease. We aimed to elucidate the genetic basis of MVP in order to better understand this complex disorder.
4,884 European ancestry cases, 434,649 European ancestry controls
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