Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
Antoni G, Oudot-Mellakh T, Dimitromanolakis A et al.
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Abstract
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Elevated levels of factor VIII (FVIII) and von Willebrand Factor (vWF) are well-established risk factors for cardiovascular diseases, in particular venous thrombosis. Although high, the heritability of these traits is poorly explained by the genetic factors known so far. The aim of this work was to identify novel single nucleotide polymorphisms (SNPs) that could influence the variability of these traits.
1,624 European ancestry individuals
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