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GWAS Study

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Chauhan G, Adams HHH, Satizabal CL et al.

30651383 PubMed ID
GWAS Study Type
23309 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CG
Chauhan G
AH
Adams HHH
SC
Satizabal CL
BJ
Bis JC
TA
Teumer A
SM
Sargurupremraj M
HE
Hofer E
TS
Trompet S
HS
Hilal S
SA
Smith AV
JX
Jian X
MR
Malik R
TM
Traylor M
PS
Pulit SL
AP
Amouyel P
MB
Mazoyer B
ZY
Zhu YC
KS
Kaffashian S
SS
Schilling S
BG
Beecham GW
MT
Montine TJ
SG
Schellenberg GD
KO
Kjartansson O
GV
Guðnason V
KD
Knopman DS
GM
Griswold ME
WB
Windham BG
GR
Gottesman RF
MT
Mosley TH
SR
Schmidt R
SY
Saba Y
SH
Schmidt H
TF
Takeuchi F
YS
Yamaguchi S
NT
Nabika T
KN
Kato N
RK
Rajan KB
AN
Aggarwal NT
DJ
De Jager PL
ED
Evans DA
PB
Psaty BM
RJ
Rotter JI
RK
Rice K
LO
Lopez OL
LJ
Liao J
CC
Chen C
CC
Cheng CY
WT
Wong TY
IM
Ikram MK
VD
van der Lee SJ
AN
Amin N
CV
Chouraki V
DA
DeStefano AL
AH
Aparicio HJ
RJ
Romero JR
MP
Maillard P
DC
DeCarli C
WJ
Wardlaw JM
HM
Hernández MDCV
LM
Luciano M
LD
Liewald D
DI
Deary IJ
SJ
Starr JM
BM
Bastin ME
MM
Muñoz Maniega S
SP
Slagboom PE
BM
Beekman M
DJ
Deelen J
UH
Uh HW
LR
Lemmens R
BH
Brodaty H
WM
Wright MJ
AD
Ames D
BG
Boncoraglio GB
HJ
Hopewell JC
BA
Beecham AH
BS
Blanton SH
WC
Wright CB
SR
Sacco RL
WW
Wen W
TA
Thalamuthu A
AN
Armstrong NJ
CE
Chong E
SP
Schofield PR
KJ
Kwok JB
VD
van der Grond J
SD
Stott DJ
FI
Ford I
JJ
Jukema JW
VM
Vernooij MW
HA
Hofman A
UA
Uitterlinden AG
VD
van der Lugt A
WK
Wittfeld K
GH
Grabe HJ
HN
Hosten N
VS
von Sarnowski B
VU
Völker U
LC
Levi C
JJ
Jimenez-Conde J
SP
Sharma P
SC
Sudlow CLM
RJ
Rosand J
WD
Woo D
CJ
Cole JW
MJ
Meschia JF
SA
Slowik A
TV
Thijs V
LA
Lindgren A
MO
Melander O
GR
Grewal RP
RT
Rundek T
RK
Rexrode K
RP
Rothwell PM
AD
Arnett DK
JC
Jern C
JJ
Johnson JA
BO
Benavente OR
WS
Wasssertheil-Smoller S
LJ
Lee JM
WQ
Wong Q
MB
Mitchell BD
RS
Rich SS
MP
McArdle PF
GM
Geerlings MI
VD
van der Graaf Y
DB
de Bakker PIW
AF
Asselbergs FW
SV
Srikanth V
TR
Thomson R
MR
McWhirter R
MC
Moran C
CM
Callisaya M
PT
Phan T
RL
Rutten-Jacobs LCA
BS
Bevan S
TC
Tzourio C
MK
Mather KA
SP
Sachdev PS
VD
van Duijn CM
WB
Worrall BB
DM
Dichgans M
KS
Kittner SJ
MH
Markus HS
IM
Ikram MA
FM
Fornage M
LL
Launer LJ
SS
Seshadri S
LW
Longstreth WT
DS
Debette S
Chapter II

Abstract

Summary of the research findings

Objective: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.

1,715 European ancestry cases, 187 African American cases, 56 Hispanic ancestry cases, 23 Chinese ancestry cases, 40 Malay ancestry cases, 13,749 European ancestry controls, 807 African American controls, 643 Hispanic ancestry controls, 173 Chinese ancestry controls, 168 Malay ancestry controls

Chapter III

Study Statistics

Key metrics and study information

23309
Total Participants
GWAS
Study Type
Yes
Replicated
630 European ancestry cases, 5,118 European ancestry controls
Replication Participants
Hispanic or Latin American, East Asian, South East Asian, European, African American or Afro-Caribbean
Ancestry
U.S., Singapore, Austria, France, Germany, Netherlands, Iceland, Republic of Ireland, U.K., Australia
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.