Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke.
Jaworek T, Xu H, Gaynor BJ et al.
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Abstract
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Background and objectives: Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke.
11,114 European ancestry cases, 435,540 European ancestry controls, 189 Admixed American ancestry cases, 948 Admixed American ancestry controls, 2,970 East Asian ancestry cases, 153,739 East Asian ancestry controls, 230 Afro-Caribbean cases, 968 Afro-Caribbean controls, 990 African ancestry cases, 3,199 African ancestry controls, 1,237 South Asian ancestry cases, 4,536 South Asian ancestry controls
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