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GWAS Study

Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

Claus EB, Cornish AJ, Broderick P et al.

29762745 PubMed ID
GWAS Study Type
14219 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CE
Claus EB
CA
Cornish AJ
BP
Broderick P
SJ
Schildkraut JM
DS
Dobbins SE
HA
Holroyd A
CL
Calvocoressi L
LL
Lu L
HH
Hansen HM
SI
Smirnov I
WK
Walsh KM
SJ
Schramm J
HP
Hoffmann P
NM
Nöthen MM
JK
Jöckel KH
SA
Swerdlow A
LS
Larsen SB
JC
Johansen C
SM
Simon M
BM
Bondy M
WM
Wrensch M
HR
Houlston RS
WJ
Wiemels JL
Chapter II

Abstract

Summary of the research findings

Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.

1,606 European ancestry cases, 9,823 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

14219
Total Participants
GWAS
Study Type
Yes
Replicated
114 European ancestry cases, 406 European ancestry controls, 418 cases, 1,852 controls
Replication Participants
European
Ancestry
U.K., Denmark, Germany, U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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