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GWAS Study

Adult Diffuse Glioma GWAS by Molecular Subtype Identifies Variants in D2HGDH and FAM20C.

Eckel-Passow JE, Drucker KL, Kollmeyer TM et al.

32386320 PubMed ID
GWAS Study Type
3709 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

EJ
Eckel-Passow JE
DK
Drucker KL
KT
Kollmeyer TM
KM
Kosel ML
DP
Decker PA
MA
Molinaro AM
RT
Rice T
PC
Praska CE
CL
Clark L
CA
Caron A
AA
Abyzov A
BA
Batzler A
SJ
Song JS
PM
Pekmezci M
HH
Hansen HM
ML
McCoy LS
BP
Bracci PM
WJ
Wiemels J
WJ
Wiencke JK
FS
Francis S
BT
Burns TC
GC
Giannini C
LD
Lachance DH
WM
Wrensch M
JR
Jenkins RB
Chapter II

Abstract

Summary of the research findings

Twenty-five germline variants are associated with adult diffuse glioma, and some of these variants have been shown to be associated with particular subtypes of glioma. We hypothesized that additional germline variants could be identified if a genome-wide association study (GWAS) were performed by molecular subtype.

622 European and unknown ancestry cases, 1,889 European and unknown ancestry controls

Chapter III

Study Statistics

Key metrics and study information

3709
Total Participants
GWAS
Study Type
Yes
Replicated
390 European and unknown ancestry cases, 808 European and unknown ancestry controls
Replication Participants
European, NR
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

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