Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study.
Newton-Cheh C, Guo CY, Wang TJ et al.
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Abstract
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Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac arrhythmias. Whereas several rare monogenic conditions with extreme phenotypes have been noted, few common genetic factors contributing to interindividual variability in ECG and HRV measures have been identified. We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits.
747 European ancestry individuals from 307 families
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