HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
McCormack M, Alfirevic A, Bourgeois S et al.
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Abstract
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Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.
65 European ancestry cases, 3,987 European ancestry controls
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