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GWAS Study

Wnt signaling and Dupuytren's disease.

Dolmans GH, Werker PM, Hennies HC et al.

21732829 PubMed ID
GWAS Study Type
12126 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DG
Dolmans GH
WP
Werker PM
HH
Hennies HC
FD
Furniss D
FE
Festen EA
FL
Franke L
BK
Becker K
VD
van der Vlies P
WB
Wolffenbuttel BH
TS
Tinschert S
TM
Toliat MR
NM
Nothnagel M
FA
Franke A
KN
Klopp N
WH
Wichmann HE
NP
Nürnberg P
GH
Giele H
OR
Ophoff RA
WC
Wijmenga C
Chapter II

Abstract

Summary of the research findings

Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis.

856 European ancestry cases, 2,836 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

12126
Total Participants
GWAS
Study Type
Yes
Replicated
1,298 European ancestry cases, 7,136 European ancestry controls
Replication Participants
European
Ancestry
Netherlands, Germany, U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.