Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
Paternoster L, Evans DM, Nohr EA et al.
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Abstract
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Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.
2,633 European ancestry extremely obese adult cases, 2,740 European ancestry controls
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