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GWAS Study

Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use.

Marees AT, Hammerschlag AR, Bastarache L et al.

29758381 PubMed ID
GWAS Study Type
39148 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MA
Marees AT
HA
Hammerschlag AR
BL
Bastarache L
DK
de Kluiver H
VF
Vorspan F
VD
van den Brink W
SD
Smit DJ
DD
Denys D
GE
Gamazon ER
LR
Li-Gao R
BE
Breetvelt EJ
DG
de Groot MCH
GT
Galesloot TE
VS
Vermeulen SH
PJ
Poppelaars JL
SP
Souverein PC
KR
Keeman R
DM
de Mutsert R
NR
Noordam R
RF
Rosendaal FR
SN
Stringa N
MD
Mook-Kanamori DO
VI
Vaartjes I
KL
Kiemeney LA
DH
den Heijer M
VS
van Schoor NM
KO
Klungel OH
MD
Maitland-Van der Zee AH
SM
Schmidt MK
PT
Polderman TJC
VD
van der Leij AR
PD
Posthuma D
DE
Derks EM
Chapter II

Abstract

Summary of the research findings

Alcohol and tobacco use are heritable phenotypes. However, only a small number of common genetic variants have been identified, and common variants account for a modest proportion of the heritability. Therefore, this study aims to investigate the role of low-frequency and rare variants in alcohol and tobacco use.

13,640 individuals

Chapter III

Study Statistics

Key metrics and study information

39148
Total Participants
GWAS
Study Type
Yes
Replicated
367 cases, 25,141 controls
Replication Participants
Netherlands, U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.