Genome-Wide Association Study of Susceptibility Loci for Radiation-Induced Brain Injury.
Wang TM, Shen GP, Chen MY et al.
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Abstract
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Radiation-induced brain injury is a nonnegligible issue in the management of cancer patients treated by partial or whole brain irradiation. In particular, temporal lobe injury (TLI), a deleterious late complication in nasopharyngeal carcinoma, greatly affects the long-term life quality of these patients. Although genome-wide association studies (GWASs) have successfully identified single nucleotide polymorphisms (SNPs) associated with radiation toxicity, genetic variants contributing to the radiation-induced brain injury have not yet been assessed.
243 cases, 839 controls
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