An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients CALGB 80303 (Alliance).
Innocenti F, Jiang C, Sibley AB et al.
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Objectives: One of the standard of care regimens for advanced pancreatic cancer is gemcitabine-based chemotherapy. The efficacy of gemcitabine is limited by dose-limiting hematologic toxicities especially neutropenia. Uncovering the variability of these toxicities attributed to germline DNA variation is of great importance.
294 European ancestry cases
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