Genetic effects on efficacy to fluticasone propionate/salmeterol treatment in COPD.
Condreay LD, Qu XA, Anderson J et al.
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Purpose: No studies have investigated genetic effects on quality of life (QoL) measurements like improvements in the St George's Respiratory Questionnaire (SGRQ) scores for chronic obstructive pulmonary disease treatments with fluticasone propionate/salmeterol (FSC). Therefore, in addition to testing genetic effects on change from baseline in trough forced expiratory volume in 1 s (FEV1), genetic associations that may predict SGRQ response to FSC treatment were investigated in this analysis.
up to 1,209 European ancestry individuals, up to 136 African, African American, South East Asian, East Asian, American Indian/Alaskan Native, Mixed race, Arabic/North African, Central/South Asian or Japanese Asian ancestry individuals
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