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Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples.

Kho M, Smith JA, Verweij N et al.

32840624 PubMed ID
GWAS Study Type
11084 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KM
Kho M
SJ
Smith JA
VN
Verweij N
SL
Shang L
RK
Ryan KA
ZW
Zhao W
WE
Ware EB
GR
Gansevoort RT
IM
Irvin MR
LJ
Lee JE
TS
Turner ST
SJ
Sung J
VD
van der Harst P
AD
Arnett DK
BA
Baylin A
PS
Park SK
SY
Seo YA
KK
Kelly KM
CY
Chang YPC
ZX
Zhou X
LJ
Lieske JC
KS
Kardia SLR
Chapter II

Abstract

Summary of the research findings

Excess sodium intake and insufficient potassium intake are risk factors for hypertension, but there is limited knowledge regarding genetic factors that influence intake. Twenty-hour or half-day urine samples provide robust estimates of sodium and potassium intake, outperforming other measures such as spot urine samples and dietary self-reporting.

6,519 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

11084
Total Participants
GWAS
Study Type
Yes
Replicated
844 European ancestry individuals, 1,246 African ancestry individuals, 2,475 Asian ancestry individuals
Replication Participants
European, African unspecified, Asian unspecified
Ancestry
Netherlands, U.S., Republic of Korea
Recruitment Country
Chapter IV

AI-Generated Summary

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