A prospective study of the associations among fine particulate matter, genetic variants, and the risk of colorectal cancer.
Chu H, Xin J, Yuan Q et al.
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Abstract
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Fine particulate matter (PM2.5) is suspected to increase the risk of colorectal cancer, but the mechanism remains unknown. We aimed to investigate the association between PM2.5 exposure, genetic variants and colorectal cancer risk in the Prostate, Lung, Colon and Ovarian (PLCO) Cancer Screening trial.
590 European ancestry cases, 55 Black cases, 9 Hispanic cases, 28 Asian ancestry cases, 5 cases, 12,715 European ancestry controls, 1,153 Black controls, 37 Hispanic controls, 94 Asian ancestry controls, 15 controls
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