Genetic variation in WNT9B increases relapse hazard in multiple sclerosis.
Vandebergh M, Andlauer TFM, Zhou Y et al.
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Abstract
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Objective: Many multiple sclerosis (MS) genetic susceptibility variants have been identified, but understanding disease heterogeneity remains a key challenge. Relapses are a core feature of MS and a common primary outcome of clinical trials, with prevention of relapses benefiting patients immediately and potentially limiting long-term disability accrual. We aim to identify genetic variation associated with relapse hazard in MS by analyzing the largest study population to date.
506 European or unknown ancestry individuals
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