Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans.
Freitag-Wolf S, Munz M, Junge O et al.
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Aims: Various studies have reported that young European women are more likely to develop early-onset periodontitis compared to men. A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes. We hypothesized that genotype-by-sex (G × S) interactions contribute to the increased prevalence and severity.
545 Dutch ancestry women, 351 Dutch ancestry men
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