Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure.
Forrest IS, Rocheleau G, Bafna S et al.
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Abstract
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Aims: Individuals with supranormal left ventricular ejection fraction (snLVEF; LVEF >70%) have increased mortality. However, the genetic and phenotypic profile of snLVEF remains unknown. This study aimed to determine the relationship of both snLVEF genetic risk and phenotype with survival and underdiagnosed heart failure (HF).
7,548 African ancestry, Hispanic, European ancestry, Asian ancestry, unknown ancestry cases, 23,009 African ancestry, Hispanic, European ancestry, Asian ancestry, unknown ancestry controls
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