Genome-wide association study of aromatase inhibitor discontinuation due to musculoskeletal symptoms.
Hertz DL, Douglas JA, Miller RM et al.
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Abstract
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Objective: Aromatase inhibitors (AIs) are commonly used to treat hormone receptor positive (HR +) breast cancer. AI-induced musculoskeletal syndrome (AIMSS) is a common toxicity that causes AI treatment discontinuation. The objective of this genome-wide association study (GWAS) was to identify genetic variants associated with discontinuation of AI therapy due to AIMSS and attempt to replicate previously reported associations.
400 White ancestry individuals
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