Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia.
Yang W, Karol SE, Hoshitsuki K et al.
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Importance: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Hepatotoxic effects, including hyperbilirubinemia and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, are common during all phases of therapy and are linked to several chemotherapeutic agents, including asparaginase, mercaptopurine, and methotrexate.
2,083 European ancestry individuals, 284 African ancestry individuals, 781 Hispanic or Latin American individuals, 142 Asian ancestry individuals, 267 individuals
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