Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach.
Butler-Laporte G, Farjoun Y, Chen Y et al.
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Abstract
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Objectives: Increased iron stores have been associated with elevated risks of different infectious diseases, suggesting that iron supplementation may increase the risk of infections. However, these associations may be biased by confounding or reverse causation. This is important, since up to 19% of the population takes iron supplementation. We used Mendelian randomization (MR) to bypass these biases and estimate the causal effect of iron on infections.
270,794 European ancestry individuals
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