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Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Study.

Naito T, Inoue K, Sonehara K et al.

36802911 PubMed ID
GWAS Study Type
34194 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

NT
Naito T
IK
Inoue K
SK
Sonehara K
BR
Baba R
KT
Kodama T
OY
Otagaki Y
OA
Okada A
IK
Itcho K
KK
Kobuke K
KS
Kishimoto S
YK
Yamamoto K
MT
Morisaki T
HY
Higashi Y
HN
Hinata N
AK
Arihiro K
HN
Hattori N
OY
Okada Y
OK
Oki K
Chapter II

Abstract

Summary of the research findings

Hypertension imposes substantial health and economic burden worldwide. Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, causing cardiovascular events at higher risk compared with essential hypertension. However, the germline genetic contribution to the susceptibility of PA has not been well elucidated.

392 Japanese ancestry cases, 33,802 Japanese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

34194
Total Participants
GWAS
Study Type
No
Replicated
East Asian, European
Ancestry
Japan, Finland, U.K.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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