Genome-wide Analysis of Motor Progression in Parkinson Disease.
Martínez Carrasco A, Real R, Lawton M et al.
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Background and objectives: The genetic basis of Parkinson disease (PD) motor progression is largely unknown. Previous studies of the genetics of PD progression have included small cohorts and shown a limited overlap with genetic PD risk factors from case-control studies. Here, we have studied genomic variation associated with PD motor severity and early-stage progression in large longitudinal cohorts to help to define the biology of PD progression and potential new drug targets.
3,572 European ancestry individuals
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