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GWAS Study

Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci.

Lori A, Pearce BD, Katrinli S et al.

38469033 PubMed ID
GWAS Study Type
5157 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

LA
Lori A
PB
Pearce BD
KS
Katrinli S
CS
Carter S
GC
Gillespie CF
BB
Bradley B
WA
Wingo AP
JT
Jovanovic T
MV
Michopoulos V
DE
Duncan E
HR
Hinrichs RC
SA
Smith A
RK
Ressler KJ
Chapter II

Abstract

Summary of the research findings

Mood disorders such as major depressive and bipolar disorders, along with posttraumatic stress disorder (PTSD), schizophrenia (SCZ), and other psychotic disorders, constitute serious mental illnesses (SMI) and often lead to inpatient psychiatric care for adults. Risk factors associated with increased hospitalization rate in SMI (H-SMI) are largely unknown but likely involve a combination of genetic, environmental, and socio-behavioral factors. We performed a genome-wide association study in an African American cohort to identify possible genes associated with hospitalization due to SMI (H-SMI).

690 African American cases, 4,467 African American controls

Chapter III

Study Statistics

Key metrics and study information

5157
Total Participants
GWAS
Study Type
No
Replicated
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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